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| Active Oxygen Species in DNA Damage Induced by Carcinogenic Metal Compounds Environ Health Perspect Key words: carcinogenic metal, chromate(VI), Fe(III) nitrilotriacetate, cobalt(II), nickel(II), DNA damage, hydrogen peroxide, hydroxyl radical, singlet oxygen, metal-oxygen complex
This paper was presented at the Second International Meeting on Molecular Mechanisms of Metal Toxiciity and Carcinogeniciity held 10-17 January 1993 in Madonna di Campiglio, Italy. Abstract
Some carcinogenic metal compounds [chromate(VI) , Fe(III) nitrilotriacetate, cobalt(II) , and nickel(II) ] induced formation of various oxygen radical species in the presence of hydrogen peroxide. These oxygen radicals were suggested to give different kinds of site-specific DNA damage ; 8-hydroxyl-2'-deoxyguanosine formation is included in the DNA damage. Using pulsed-field gel electrophoresis, nickel sulfide was shown to induce oxidative DNA cleavage in cultured cells. On the basis of these findings, we have emphasized the role of oxygen radicals in metal carcinogenesis. --- Environ Health Perspect 102(Suppl 3) :17-20 (1994) . Key words: carcinogenic metal, chromate(VI) , Fe(III) nitrilotriacetate, cobalt(II) , nickel(II) , DNA damage, hydrogen peroxide, hydroxyl radical, singlet oxygen, metal-oxygen complex
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