Epidemiology of Cancer from Exposure to Arylamines

P. Vineis
p. 7

Analysis of 4-Aminobiphenyl-DNA Adducts in Human Urinary Bladder and Lung by Alkaline Hydrolysisand Negative Ion Gas Chromatography-Mass Spectrometry

D. Lin, J.O. Lay, M.S. Bryant, C. Malaveille, M. Friesen, H. Bartsch, N.P. Lang, and F.F. Kadlubar
p. 11

Molecular Dosimetry of Aromatic Amines in Human Populations

P.L. Skipper and S.R. Tannenbaum
p. 17

Biological Monitoring of Exposure to 3-Chloro-4-fluoroaniline by Determination of a Urinary Metabolite and a Hemoglobin Adduct

P.J. Boogard, G.D.J. Beulink, and N.J. van Sittert
p. 23

Molecular Dosimetry of 2,4-Diuoroaniline in Humans and Rats by Determination of Hemoglobin Adducts

P.J. Boogard, G.N. Fokkema, G.D.J. Beulink, J. Bouskill, and N.J. van Sittert
p. 27

Development of Methods to Monitor Exposure to 1-Nitropyrene

K. El-Bayoumy, B. Johnson, A.K. Roy, P. Upadhyaya, S. Partian, and S.S. Hecht
p. 31

Nitroreduction and Formation of Hemoglobin Adducts in Rats with a Human Intestinal Microora

P.T.J. Scheepers, M.M.E. Straetemans, J.P. Koopman, and R.P. Bos
p. 39

Hydrolyzable Hemoglobin Adducts of Polyfunctional Monocyclic N-Substituted Arenes as Dosimeters of Exposure and Markers of Metabolism

I. Zwirner-Baier, F-J. Kordowich, and H-G. Neumann
p. 43

Species Differences in Metabolism of Heterocyclic Aromatic Amines, Human Exposure, and Biomonitoring

R.J. Turesky, G.A. Gross, W.G. Stillwell, P.L. Skipper, and S.S. Tannenbaum
p. 47

The Role of Fat and Calcium in the Production of Foci of Aberrant Crypts in the Colon of Rats Fed 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

J.H. Weisburger, J. Braley, J. Reinhardt, C. Aliaga, A. Rivenson, G.C. Hard, X.M. Zhang, M. Takahasai, H. Esumi, and T. Sugimura
p. 53

Dietary Modulation of DNA Adduct Formation of the Food Mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the Male Fischer 344 Rat

H.A.J. Schut
p. 57

Hemoglobin Binding of Arylamines and Nitroarenes: Molecular Dosimetry and Quantitative Structure-Activity Relationships

G. Sabbioni
p. 61

Metabolism

Cytosolic Activation of Aromatic and Heterocyclic Amines. Inhibition by Dicoumarol and Enhancement in Viral Hepatitis B

S. De Flora, C. Bennicelli, F. D'Agostini, A. Izzotti, and A. Camoirano
p. 69

Peroxidative Metabolism of Carcinogenic N-Arylhydroxamic Acids: Implications for Tumorigenesis

D. Malejka-Giganti and C.L. Ritter
p. 75

N-Hydroxyarylamine O-Acetyltransferase of Salmonella typhimurium: Proposal for a Common Catalytic Mechanism of Arylamine Acetyltransferase Enzymes

M. Wantanabe, T. Igarashi, T. Kaminuma, T. Sofuni, and T. Nohmi
p. 83

Characterization of Rat Hepatic Acetyltransferase

S.J. Land and C.M. King
p. 91

Arylamines Suppress Their Own Activation and that of Nitroarenes in V79 Chinese Hamster Cells by Competing for Acetyltransferases

F. Kiefer, O. Cumpelik, R. Reen, J. Doehmer, and F.J. Wiebel
p. 95

Characterization and Expression of Hepatic Sulfotransferase Involved in the Metabolism of N-Substituted Aryl Compounds

Y.Yamazoe, S. Ozawa, K. Nagata, D-W. Gong, and R. Kato
p. 99

Modulations of Hepatic -Glutamyltranspeptidase and N-Hydroxy-N-2-uorenylacetamide Sulfotransferase Activities following Treatment of Rats with a Hepatocarcinogenic Regimen: Effect of Partial Hepatectomy

P. Vijayaraghavan and D. Malejka-Giganti
p. 105

Metabolism of the Food Mutagen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Isolated Liver Cells from Guinea Pig, Hamster, Mouse, and Rat

J. Alexander, B.H. Fossum, and J.A. Holme
p. 109

Oxidative Conversion of Isothiocyanates to Isocyanates by Rat Liver

M-S. Lee
p. 115

Evidence for Direct-acting Oxidative Genotoxicity by Reduction Products of Azo Dyes

E.A. Sweeney, J.K. Chipman, and S.J. Forsythe
p. 119

Reactions of Oxidatively Activated Arylamines with Thiols: Reaction Mechanisms and Biologic Implications. An Overview

P. Eyer
p. 123

Structural Requirements for the Ferrihemoglobin-forming Activity of Glutathione S-Conjugates of 4-Dimethylaminophenol

E. Ludwig and P. Eyer
p. 133

Additional Pathways of S-Conjugate Formation during the Interaction of Thiols with Nitrosoarenes Bearing -Donating Substituents

D. Gallemann and P. Eyer
p. 137

Synthetic and Oxidative Studies on 8-(Arylamino)-2´-deoxyguanosine and -Guanosine Derivatives 143

F. Johnson, C-Y. Huang, and P-L. Yu
p. 143

A Selective Synthesis of 4-Aminobiphenyl-N²-deoxyguanosine Adducts

S. Scheer, T. Steinbrecher, and G. Boche
p. 151

Genotoxic and Nongenotoxic Mechanisms

Metabolic Activation Routes of Arylamines and Their Genotoxic Effects

J.H.N. Meerman and M.L.M. van de Poll
p. 153

DNA Adduct Measurements and Tumor Incidence during Chronic Carcinogen Exposure in Rodents

M.C. Poirier and F.A. Beland
p. 161

DNA Adducts in Target and Nontarget Tissues of 3-2´-Dimethyl-4-aminobiphenyl in Rats

T. Shirai, M. Tada, M. Kojima, R. Hasegawa, T. Masui, and N. Ito
p. 167

The Role of Nongentoxic Mechanisms in Arylamine Carcinogenesis

H-G. Neumann, S. Ambs, and A. Bitsch
p. 173

DNA Adducts and Carcinogenicity of Nitro-polycyclic Aromatic Hydrocarbons

P.P. Fu, D. Herreno-Saenz, L.S. Von Tungeln, J.O. Lay, Y-S. Wu, J-S. Lai, and F.E. Evans
p. 177

Formation of DNA Adducts and Induction of Mutations in Rats Treated with Tumorigenic Doses of 1,6-Dinitropyrene

F.A. Beland, N.F. Fullerton, B.A. Smith, and R.H. Heich
p. 185

The Carcinogenicity of Methoxyl Derivatives of 4-Aminoazobenzene: Correlation between DNA Adducts and Genotoxicity

M. Kojima, M. Degawa, Y. Hashimoto, and M. Tada
p. 191

Mutagenesis, Gene Activation, and Genetic Determinants

Pathways for the Mutagenesis of 1-Nitropyrene and Dinitropyrenes in the Human Hepatoma Cell Line HepG2

K.J. Silvers, E. P. Eddy, E.C. McCoy, H.S. Rosenkranz, and P.C. Howard
p. 195

Mutagenic Activity of Heterocyclic Amines in Cooked Foods

J.S. Felton, M.G. Knize, F.A. Dolbeare, and R. Wu
p. 201

Gene Activation Studied by Immunological Methods

H.S. Huitfeldt, A. Heyden, E. Skarpen, E.V. Thrane, and P.E. Schwarze
p. 205

Requirement for Metabolic Activation of Acetylaminofluorene to Induce Multidrug Gene Expression

T.W. Gant, D. Schrenk, J.A. Silverman, and S.S. Thorgeirsson
p. 209

Polymorphism of Human Acetyltransferases

U.A. Meyer
p. 213

Modification of Plasmid and Bacteriophage DNA by Aromatic Amines: Effects on Survival, Template Activity, and Mutagenicity

C.M. King, M-S. Lee, R.F. Jones, and N. Tamura
p. 217

Last update: October 23, 1998