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| Workshop on Perinatal Exposure to Dioxin-like Compounds. V. Immunologic Effects Linda S. Birnbaum Environmental Toxicology Division Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina Abstract
The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compounds following prenatal exposure involved a review of the immunotoxic effects which have been reported for polyhalogenated aromatic hydrocarbons (PHAHs) (Nancy Kerkvliet) , a discussion of species differences in responses (Ralph Smialowicz) and development of the immune system (Tom Gasiewicz) , and data from two ongoing epidemiological studies comparing the immune status of children exposed to higher than average concentrations of PHAHs both prenatally and lactationally (Eric Dewailly - Inuits in Quebec ; Hans Helge - Germany) . -- Environ Health Perspect 103(Suppl 2) :157-160 (1995) Key words: T CDD, PCBs, immunosuppression, thymic atrophy, T-lymphocyte subsets
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