| Workshop on Perinatal Exposure to Dioxin-like Compounds. III. Endocrine Effects M. Mark Feeley Bureau of Chemical Safety, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario, Canada Abstract
Studies involving endocrine effects in humans and experimental animals resulting from the exposure to dioxin-like (non-ortho-substituted PCBs, PCDDs/PCDFs) and nondioxin-like (PCBs, OC pesticides) compounds (DLCs and NDLCs) were presented. A variety of reproductive and hormonal parameters, including androgen status, sexual differentiation, and thyroid functionality, were discussed. As in utero and lactational exposure of the human fetus/neonate to these environmental contaminants is inevitable, continued research to identify sensitive biomarkers of effect and susceptibility, as well as to define dose-response relationships, is required. -- Environ Health Perspect 103(Suppl 2) :147-150 (1995) Key words: PCBs, PCDDs/PCDFs, environmental estrogens, perinatal, transplacental, lactational, endocrinology, thyroid hormones, T3/T4, neonatal
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