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The National Cancer Institute
The National Cancer Institute is looking for a tenure-track scientist to develop a program of pre-clinical and mechanistic studies evaluating the effects of oxidants on tumor modulation and normal tissue physiology and cytotoxicity. Send a brief statement of research interests, C.V., bibliography, selected publications and three reference letters to Marie Priest, Division of Clinical Science, NCI, Bldg. 31, Room 3A11, 31 Center Drive, MSC 2440, Bethesda, M D 20892-2440
National Institute of Allergy and Infectious Diseases: Molecular Biology and Immunology
A novel group of genes termed RGSs that are involved in regulating signal transduction through G-protein-linked receptors are being studied. Several of these genes are expressed at high levels in lymphoid cells. Emphasis is upon characterizing the various family members, understanding the mechanism by which the family members impair G-protein signaling, and targeted disruption of various family members in mice. Position is available immediately. Applicants must have a PhD and or MD and less than five years of postdoctoral experience. For information, contact John H. Kehrl, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Building 10, Room 11B08, 10 Center Dr. MSC 1876, Bethesda, MD 20892-1876. (301) 402-4852. FAX (301) 402-0070. e-mail: Jkehrl@nih.gov. Reference: Entry ID: PD-0074
National Cancer Institute
Experimental Molecular Information Theory
In March of 1997, there will be a position available for a postdoc to conduct molecular biology experiments testing theoretical predictions from information theory analysis. Although the projects are heavily intertwined with mathematical and computer work, I will only consider people willing and able to do bench work. The projects are cutting-edge science. The position can start sooner than March 1997 to allow some overlap with current postdoc. The position is an NIH Postdoctoral Intramural Research Training Award (IRTA). Further information about the project can be found at the following URLs:
http://www-lmmb.ncifcrf.gov/~toms/postdoc.html
http://www-lmmb.ncifcrf.gov/~toms/
For more information, contact: Tom Schneider, National Cancer Institute, Laboratory of Mathematical Biology, Division of Basic Sciences, National Cancer Institute/ Frederick Cancer Research and Development Center (NCI/FCRDC), Building 469, Room 144, PO Box B, Frederick, MD 21702-1201. (301) 846-5581. FAX (301) 946-5598. e-mail: toms@ncifcrf.gov. Reference: Entry ID: PD-0082
Retinal Anatomy/Physiology
Postdoctoral Position availbable now to work on NIH-funded study of interactions between rod and cone signals in macaque monkey retina. Training is offered in physiology and anatomy of primate retina in the lab of Dr. Dennis Dacey (Department of Biological Structure). Background in electrophysiology, visual psychophysics, and/or color science would be helpful. Annual salary: $25,000 for one to three years. Please send curriculum vitae and names of three references to : Dr. Steven Buck, Department of Psychology, University of Washington, Box 351525, Seattle, WA 98195. FAX: 206-685-3157, e-mail: sbuck@u. washington.edu
Public Health Scientist
The Natural Resources Defense Council, a national nonprofit public interest organization, seeks a Senior Scientist to bring scientific analysis and knowledge to advocacy in various forums for the prevention of adverse health and ecological effects of toxic chemical pollution. A PhD or MD/MD with 5 or more years highly relevant experience is required. Candidates should be knowledgeable about cutting-edge toxics issues such as disproportionately impacted subpopulations, noncancer endpoints, and emerging issues regarding carcinogenesis. The salary is $50,000- $65,000, commensurate with experience. Send resume to: Public Health Program, NRDC, 1350 New York Avenue, NW, Suite 300, Washington, DC 20005. Equal Opportunity Employer.
Postdoctoral Research Opportunities at the National Institute of Environmental Health Sciences
Listed below are outstanding opportunities to conduct research with leading scientists in Research Triangle Park, North Carolina.
To be eligible, applicants must not possess more than five years of postdoctoral experience. To apply send a cover letter, curriculum vitae, bibliography, and names of three references to the hiring scientist at the maildrop and laboratory listed using the following address: NIEHS, PO Box 12233, Research Triangle Park, North Carolina 27709. In your cover letter, list the position title and the HNV number. Current postdoctoral vacancies are accessible on the internet at the address http://www.niehs.nih.gov/omhrmb/vacancy.htm or on the NIEHS Jobline, (919) 541-4331.
Minorities, women and handicapped individuals are encouraged to apply. All applicants receive consideration without regard to race, religion, color, national origin, sex, physical or mental handicap, political affiliation, age (with statutory exceptions) or any other nonmerit factor. Positions are open until filled.
Molecular Neurobiology (HNV94)
The signal transduction pathways regulating the expression of neuropeptide and cytokine genes in neural and glial systems are being investigated. Studies on the effects of neuropeptides on the biosynthesis and release of cytokines in microglial cells and potential roles of cytokines in neurodegeneration will be conducted. Applicants should have experience in neuropharmacology, neurochemistry or molecular biology.
Contact: J.S. Hong, (919) 541-2358, Laboratory of Environmental Neurosciences, Maildrop E1-01, e-mail: Hong3@niehs.nih.gov
Characterization of Receptor-Ligand Interactions (HNV96-1)
Mass spectrometry combined with protection assays is being used to probe structural motifs involved in molecular interactions, such as the interaction of HIV rgp120 and immunoglobin, relevant to an understanding of the basic processes occurring during HIV viral infection. Candidates should have expertise in protein and immunochemistry.
Contact: Kenneth Tomer, (919) 541-1966, Laboratory of Molecular Biophysics, Maildrop 6-01, e-mail: Tomer@niehs.nih.gov
Xenobiotic Transport Mechanisms (HNV96-9)
We use fluorescent substrates, confocal microscopy, and image analysis to characterize xenobiotic transport mechanisms in renal and nonrenal epithelial tissues. The focus is on understanding the specificities, energetics, and regulation of both plasma membrane transporters and intracellular mechanisms such as vesicle-mediated transcytosis. Experience in the biochemistry and physiology of membrane transport is expected. Position available October 1, 1996.
Contact: David S. Miller, (919) 541-3532, Laboratory of Cellular and Molecular Pharmacology, Maildrop 7-01, e-mail: Miller@niehs.nih.gov
Renal Transport Physiology (HNV96-10)
The transport mechanisms responsible for elimination of xenobiotics are studied in epithelial tissues including kidney and choroid plexus. Applicant will examine the mechanisms and energetics of organic anion transport using cultured monolayers and isolated membrane vesicles. Experience in the biochemistry or physiology of membrane function is expected. Position available August 1, 1996.
Contact: John Pritchard, (919) 541-4054, Laboratory of Cellular and Molecular Pharmacology, Maildrop 19-02, e-mail: Pritchard@niehs.nih.gov
Cell Adhesion in Metastasis (HNV96-11)
Current research focuses on understanding cell adhesion as it functions in cancer metastasis and on efforts to inhibit various steps in the metastatic process. We are attempting to define the factors that modulate cell adhesion, such as fatty acids and their metabolites, the integrins involved in adhesion, and the role of signal transduction in this process. We are using both human breast carcinoma cells and prostate carcinoma cells as model systems both in culture and in an in vivo mouse model. We have a special interest in the role of protein glycosylation in metastasis and in glycosylation inhibitors and their ability to block metastasis, either by interfering with tumor cell function or by stimulating the host's immune responses. The applicant should have a PhD or equivalent and training in cancer biology and molecular biology.
Contact: John Roberts, (919) 541-5023, Laboratory of Molecular Carcinogensis, Maildrop C2-14, e-mail: Roberts@niehs.nih.gov
Xenbiotic Metabolism (HNV96-14)
A postdoctoral position is available to conduct research in xenobiotic metabolism and mechanisms of toxicity on chemicals under study by the National Toxicology Program. The ideal candidate will have experience in isolation and identification of metabolites from in vivo and in vitro studies, a basic understanding of xenobiotic metabolism, and a desire to understand how the biotransformation of a chemical is related to its toxicity. Contact Leo T. Burka, (919) 541-4667, Environmental Toxicology Program, Chemistry Branch, Maildrop B3-10, e-mail: burka@niehs.nih.gov
Mechanistic Aspects of DNA Mismatch Repair on Recombination (HNV96-16)
The primary focus of this laboratory centers around determining the mechanism(s) by which E. coli methyl directed repair controls the level of recombination between related but non identical sequences. Previous genetic studies have provided evidence demonstrating that homeologous recombination increases in strains deficient in mismatch repair with the strongest effects observed in MutS - and MutL - backgrounds. This observation stimulated us to further pursue the molecular basis for such an effect. An in vitro assay has been devised that allows us to directly assess individual activities of mismatch repair using the model three & four strand transfer reaction catalyzed by E. coli RecA protein. In addition, studies are presently being undertaken to address several other components of mismatch repair and recombination including E. coli RuvAB proteins, RecG and other activities involved in the mismatched provoked excision reaction.
Contact: Leroy Worth, Jr., (919) 541-0670 Laboratory of Molecular Genetics, Maildrop D3-03
e-mail: worth@niehs.nih.gov
Molecular and Cellular Biology (HNV97)
The action and function of several nuclear (orphan) receptors in the regulation of gene expression and differentiation are being investigated. Studies involve characterization of response elements, interaction with other transcriptional factors and gene knockouts. Applicants must have training in molecular biology techniques.
Contact: Anton Jetten, (919) 541-2768, Laboratory of Pulmonary Pathobiology, Maildrop D2-01, e-mail: Jetten@niehs.nih.gov
Mechanisms by which Organisms Produce Mutations (HNV99)
Studies are aimed at understanding the mechanisms by which organisms produce mutations. Specific projects involve the isolation and molecular characterization of antimutator mutants in the bacterium E. coli; the genetic and biochemical analysis of DNA replication fidelity in this organism; and a structure-function analysis of the dnaE and dnaQ genes (encoding, respectively, the DNA polymerase and exonucleolytic proofreading activity).
Contact: Roel M. Schaaper, (919) 541-4250, Laboratory of Molecular Genetics, Maildrop E3-01, e-mail: Schaaper@niehs.nih.gov
Molecular Mechanisms of Respiratory Diseases (HNV110)
This is a tenure track position to develop an independent research program in cellular and molecular mechanisms of respiratory biology and diseases. Extensive postdoctoral experience in molecular biology, developmental biology, signal transduction or biochemical mechanisms of inflammation is required.
Contact: Paul Nettesheim, (919) 541-3540, Laboratory of Pulmonary Pathobiology, Maildrop D2-01, e-mail: Nettesheim@niehs.nih.gov
Molecular Biology and Fatty Acid Biochemistry (HNV112)
Novel human cytochrome P450 enzymes that metabolize fatty acids are cloned and expressed, and the catalytic properties of the recombinant, purified proteins are evaluated by HPLC. Regulation of the gene expression is studied using Northern analysis, RT-PCR, and protein immunoblotting, immunohistochemistry and in situ hybridization. Applicants should have a strong background in cell and molecular biology.
Contact: Darryl Zeldin, (919) 541-1169, Laboratory of Pulmonary Pathobiology, Maildrop D2-01, e-mail: Zeldin@niehs.nih.gov
National Institute of Environmental Health Sciences, Student Job Opportunities
The National Institute of Environmental Health Sciences (NIEHS) is currently accepting applications for temporary employment under the Student Temporary Employment Program. The Student Temporary Employment Program provides an
excellent opportunity for students to gain valuable work experience and earn income while pursuing a degree. Students may work full-time during the summer or when school is closed and arrange their work schedule around their academic schedule while school is in session. To be eligible, students need to be at least 16 years of age, be enrolled or accepted for enrollment as a degree seeking student taking at least a half-time academic, vocational, or technical course load in an accredited high school, technical or vocational school, or 2 year or 4 year college or university,
graduate school, or professional school. Student Temporary Employment Program employees are paid commensurate with their qualifications and the assigned duties of the position, with a minimum of $6.18 per hour (GS-1) or 6.78 per hour (WG-1). Instructions for applying: Although the Federal Government does not require a standard application form, we do need certain information to evaluate your qualifications and determine if you meet legal requirements for Federal employment. Submit a current copy of your resume; SF-171, Application for Federal Employment; OF-612, Optional Application for Federal Employment; or any other written format you choose that includes education, work experience, and any other job related qualifications. Also include a letter from the Registrar's Office verifying your academic standing and enrollment status, graduate and undergraduate college transcripts or OPM Form 1170, and Green Card if permanent resident.
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Last Update: August 8, 1997
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