| Risk Assessment for Neurobehavioral Toxicity: SGOMSEC Joint Report Environ Health Perspect Key words: benchmark dose, effect levels, identification of neurotoxicity, interindividual variability, quantitative models, reference doses, regulatory activity, reversibility Abstract
Behavioral end points for neurotoxicity risk assessment have been developed and examined over the past three decades. They are now ready to move from simple qualitative guidelines, such as exemplified by reference doses, to more quantitative models, such as benchmark doses, based on dose-response information. Risk assessors, confronted by a wider array of methodologies and data than in the past, should be offered guidance in interpretation because now they have to deal with unaccustomed questions and problems. These include reversibility, susceptible populations, multiple end points, and the details of dose-response and dose-effect distributions. -- Environ Health Perspect 104(Suppl 2) :217-226 (1996) Key words: benchmark dose, effect levels, identification of neurotoxicity, interindividual variability, quantitative models, reference doses, regulatory activity, reversibility
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