Environmental Health Perspectives 104, Supplement 5, October 1996

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Breath Measurements as Volatile Organic Compound Biomarkers

Lance Wallace,¹ Timothy Buckley,¹ Edo Pellizzari,² and Sydney Gordon³

¹Atmospheric Research and Exposure Assessment Laboratory, U.S. Environmental Protection Agency, Reston, Virginia
²Research Triangle Institute, Research Triangle Park, North Carolina
³Battelle Memorial Institute, Columbus, Ohio

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Abstract
A brief review of the uses of breath analysis in studies of environmental exposure to volatile organic compounds (VOCs) is provided. The U.S. Environmental Protection Agency's large-scale Total Exposure Assessment Methodology Studies have measured concentrations of 32 target VOCs in the exhaled breath of about 800 residents of various U.S. cities. Since the previous 12-hr integrated personal air exposures to the same chemicals were also measured, the relation between exposure and body burden is illuminated. Another major use of the breath measurements has been to detect unmeasured pathways of exposure; the major impact of active smoking on exposure to benzene and styrene was detected in this way. Following the earlier feld studies, a series of chamber studies have provided estimates of several important physiological parameters. Among these are the fraction, f, of the inhaled chemical that is exhaled under steady-state conditions and the residence times, _i in several body compartments, which may be associated with the blood (or liver), organs, muscle, and fat. Most of the targeted VOCs appear to have similar residence times of a few minutes, 30 min, several hours, and several days in the respective tissue groups. Knowledge of these parameters can be helpful in estimating body burden from exposure or vice versa and in planning environmental studies, particularly in setting times to monitor breath in studies of the variation with time of body burden. Improvements in breath methods have made it possible to study short-term peak exposure situations such as flling a gas tank or taking a shower in contaminated water. -- Environ Health Perspect 104(Suppl 5):861-869 (1996)

Key words: breath measurements, volatile organic compounds, benzene, aromatics, aliphatics, terpenes, halocarbons, chlorinated chemicals, TEAM Study

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This paper was presented at the Conference on Air Toxics: Biomarkers in Environmental Applications held 27-28 April 1995 in Houston, Texas. Manuscript received 24 May 1996; manuscript accepted 5 June 1996.

Address correspondence to Dr. L. Wallace, Atmospheric Research and Exposure Assessment Laboratory, U.S. EPA, 11568 Woodhollow Court, Reston, VA 22091. Telephone: (540) 341-7509. Fax: (703) 860-0678. E-mail: wallace.lance@epamail.epa.gov

Abbreviations used: API, atmospheric pressure ionization; GC-MS, gas chromatography-mass spectroscopy; MS-MS, tandem mass spectroscopy; MTBE, methyl-tert-butyl ether; PBPKs, physiologically based pharmacokinetics; TEAM, total exposure assessment methodology; TLV, threshold limit value; U.S. EPA, U.S. Environmental Protection Agency; VOCs, volatile organic compounds.

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