Albert R. Cunningham,1 Gilles Klopman,2 and Herbert S. Rosenkranz1
1Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania; 2Department of Chemistry, Case Western Reserve University, Cleveland, Ohio
Using two independent analyses, it is demonstrated that natural (e.g., estradiol) and some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding to specific receptors and may, in fact, differentiate harmful from beneficial estrogens. -- Environ Health Perspect 105(Suppl 3):665-668 (1997)
Key words: CASE/MULTICASE, cancer, estrogens, lipophilicity
This paper was presented in part at the Workshop on Hormones, Hormone Metabolism, Environment, and Breast Cancer held 28-29 September 1995 in New Orleans, Louisiana. Manuscript received at EHP 6 June 1996; manuscript accepted 21 August 1996.
This investigation was supported by the U.S. Department of Defense (contract DAAA21-93-C-0046) and the Predoctoral Training in Breast Cancer Biology and Therapy Fellowship awarded by the U.S. Army Medical Research and Acquisition Activity. Additionally, the authors thank the reviewer for the insightful comments and suggestions.
Address correspondence to Dr. H.S. Rosenkranz, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261. Telephone: (412) 967-6510. Fax: (412) 624-1289. E-mail:rsnkranz@vms.cis.pitt.edu
Abbreviations used: CASE, computer atomated structure evaluator; 2D, 2-dimensional distance; DES, diethylstilbestrol; MMP, Molecular Modeling Pro; MULTICASE, multiple case.
Last Update: April 10, 1997