Environmental Health Perspectives 105, Supplement 1, February 1997

Recent Molecular Advances in the Approach to Early Lung Cancer Detection and Intervention

James L. Mulshine, Frank Scott, Jun Zhou, Ingalill Avis, Michele Vos, and Anthony M. Treston

Division of Clinical Science, National Cancer Institute, Rockville, Maryland

Abstract
Lung cancer is a major contributor to overall cancer mortality. Detecting lung cancer while it is still a localized process is a long-cherished goal for improving the outcome of this disease. Recent developments suggest that we are approaching this capability. We next have to think about how to implement a change in our approach to lung cancer management to derive the benefit of better detection capability. This is an area in which our growing understanding of lung cancer biology is providing clues on improving the inhibition of cancer progression. -- Environ Health Perspect 105(Suppl 4):935-939 (1997)

Key words: lung cancer, molecular diagnostics, early detection, carcinogenesis, apoptosis

This paper is based on a presentation at the symposium on Mechanisms and Prevention of Environmentally Caused Cancers held 21-25 October 1995 in Santa Fe, New Mexico. Manuscript received at EHP 16 April 1996; accepted 6 August 1996.
Address correspondence to Dr. J.L. Mulshine, Biomarkers and Prevention Research Branch, Division of Clinical Science, National Cancer Institute, KWC 300, 9610 Medical Center Drive, Rockville, MD 20850-3300. Telephone: (301) 402-3128. Fax: (301) 402-4422. E-mail: mulshine@bprb.nci.nih.gov
Abbreviation used: IGF-I, insulinlike growth factor-I.

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Last Update: June 23, 1997