Environmental Health Perspectives 105, Supplement 5, September 1997

[ Citation in PubMed ] [ Related Articles ]

Dose-Response Relationship of Fibrous Dusts in Intraperitoneal Studies

Markus Roller, 1 Friedrich Pott, 1 Kenji Kamino, 2 Gerhard-Heinrich Althoff, 1 and Bernd Bellmann 3

1 Department of Experimental Hygiene, Medical Institute of Environmental Hygiene at the Heinrich Heine University, Düsseldorf, Germany
2 Institute of Experimental Pathology, Hannover Medical School, Hannover, Germany
3 Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany

Abstract
The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies with several fibrous dusts. Based on observed tumor incidences ranging between 10 and 90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action. Analysis of the shape of the dose-response relationship, with one apparent exception, shows virtually linear or superlinear behavior, i.e., from these data, there is no indication of a decrease in carcinogenic potency of an elementary carcinogenic unit at lower doses. -- Environ Health Perspect 105(Suppl 5):1253-1256 (1997)

Key words : asbestos, vitreous fibers, carcinogenicity, abdominal cavity, mesothelioma, rat, dose response, linearity

This paper is based on a presentation at The Sixth International Meeting on the Toxicology of Natural and Man-Made Fibrous and Non-Fibrous Particles held 15-18 September 1996 in Lake Placid, New York. Manuscript received at EHP 26 March 1997; accepted 11 April 1997.

Address correspondence to Dr. M. Roller, Medical Institute of Environmental Hygiene at the Heinrich Heine University, Auf'm Hennekamp 50, D-40225 Düsseldorf, Germany. Telephone: 49 211 3389 302. Fax: 49 211 3190910.

Abbreviations used: df, degrees of freedom; MMVF, man-made vitreous fiber(s).

[ Table of Contents ] [ Full Article ] [ Citation in PubMed ] [ Related Articles ]

Last Update: November 18, 1997