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| Genetic Predispositions and Childhood Cancer Kevin Shannon Department of Pediatrics, University of California, San Francisco, California Abstract
This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemia is used to illustrate some of the issues faced by molecular biologists and genetic epidemiologists in identifying and analyzing at-risk individuals. The problem of incomplete penetrance in cancer susceptibility is presented and potential models are discussed. The article concludes with a number of tentative conclusions from existing data and speculations for future studies. -- Environ Health Perspect 106(Suppl 3) :801-806 (1998) . http://ehpnet1.niehs.nih.gov/docs/1998/Suppl-3/801-806shannon/abstract.html Key words: cancer predispositions, tumor-suppressor genes, neurofibromatosis type 1, childhood cancer
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