| Tetrachloroethylene-Contaminated Drinking Water and the Risk of Breast Cancer Ann Aschengrau,1 Christopher Paulu,2 and David Ozonoff2 1Department of Epidemiology and Biostatistics,
2Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts
Abstract
We conducted a population-based case-control study to evaluate the relationship between cases of breast cancer and exposure to tetrachloroethylene (PCE) from public drinking water (n=258 cases and 686 controls) . Women were exposed to PCE when it leached from the vinyl lining of water distribution pipes. The relative delivered dose was estimated using an algorithm that accounted for residential history, water flow, and pipe characteristics. Only small increases in breast cancer risk were seen among ever-exposed women either when latency was ignored or when 5 to 15 years of latency was considered. No or small increases were seen among highly exposed women either when latency was ignored or when 5 years of latency was considered. However, the adjusted odds ratios (ORs) were more increased for highly exposed women when 7 and 9 years of latency, respectively, were considered (OR 1.5, 95% CI 0.5-4.7 and OR 2.3, 95% CI 0.6-8.8 for the 75th percentile, and OR 2.7, 95% CI 0.4-15.8 and OR 7.6, 95% CI 0.9-161.3 for the 90th percentile) . The number of highly exposed women was too small for meaningful analysis when more years of latency were considered. Because firm conclusions from these data are limited, we recently undertook a new study with a large number of more recently diagnosed cases. -- Environ Health Perspect 106(Suppl 4) :947-953 (1998) . http://ehpnet1.niehs.nih.gov/docs/1998/Suppl-4/947-953aschengrau/abstract.html Key words: t etrachloroethylene, drinking water, pollution, cancer
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