| Childhood Asthma Noreen M. Clark,1 Randall W. Brown,2 Edith Parker,1 Thomas G. Robins,3 Daniel G. Remick Jr,2 Martin A. Philbert,3 Gerald J. Keeler,3 and Barbara A. Israel1 1University of Michigan School of Public Health Department of Health, Behavior and Health Education, 2University of Michigan Medical School, 3University of Michigan School of Public Health, Department of Environmental and Industrial Health, Ann Arbor, Michigan USA Abstract
Asthma prevalence in children has increased 58% since 1980. Mortality has increased by 78%. The burden of the disease is most acute in urban areas and racial/ethnic minority populations. Hospitalization and morbidity rates for nonwhites are more than twice those for whites. Asthma is characterized by recurrent wheezing, breathlessness, chest tightness, and coughing. Research in the past decade has revealed the importance of inflammation of the airways in asthma and clinical treatment to reduce chronic inflammation. Asthma is associated with production of IgE to common environmental allergens including house dust mite, animal dander, cockroach, fungal spores, and pollens. Some interventions to reduce symptoms through control of dust mite and animal dander have had positive results. Control of symptoms through interventions to reduce exposures to cockroach antigen has not been reported. Studies illustrating causal effects between outdoor air pollution and asthma prevalence are scant. Increases in asthma prevalence have occurred at the same time as general improvements in air quality. However, air quality appears to exacerbate symptoms in the child who already has the disease. Decreased pulmonary function has been associated with exposure to particulates and bronchial hyperresponsiveness to smoke, SO2 and NO2. Symptoms have been correlated with increased levels of respirable particulates, ozone, and SO2. Interventions that reduce the negative outcomes in asthma associated with outdoor environmental factors have not been reported. Control of asthma in children will entail the collaborative efforts of patients, family, clinical professionals, and school personnel, as well as community-wide environmental control measures and conducive national and local policies based on sound research. Key words: asthma control, child health, childhood asthma, environmental precipitants. -- Environ Health Perspect 107(suppl 3) :421-429 (1999) . http://ehpnet1.niehs.nih.gov/docs/1999/suppl-3/421-429clark/abstract.html
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