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Environmental Health Perspectives Supplements Volume 107, Number S5, October 1999
Environmental Health Perspectives Supplements October 1999 Linking Environmental Agents to Autoimmune Diseases

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Degradation of the immune system by external agents (symbolized by the crushing grasp) may result in loss of self-recognition leading to disease and ultimately self-destruction.

Linking Environmental Agents to Autoimmune Diseases

Introduction: Linking Environmental Agents and Autoimmune Diseases
Glinda S. Cooper, Dori Germolec, Jerry Heindel, and MaryJane Selgrade
p. 659

Overview

Introduction to Immunology and Autoimmunity
Dorinda A. Smith and Dori R. Germolec
p. 661

Evidence for the Role of Environmental Agents in the Initiation or Progression of Autoimmune Conditions
Jonathan J. Powell, Judy Van de Water, and M. Eric Gershwin
p. 667

Screening Tests for Autoimmune-related Immunotoxicity
Raymond Pieters and Ruud Albers
p. 673

Autoimmunity and Risk Assessment
Michael I. Luster, Petia P. Simeonova, Randy Gallucci, and Joanna Matheson
p. 679

Susceptibility

Gender and Risk of Autoimmune Diseases: Possible Role of Estrogenic Compounds
S. Ansar Ahmed, B.D. Hissong, D. Verthelyi, K. Donner, K. Becker, and E. Karpuzoglu-Sahin
p. 681

Prenatal Immunotoxicant Exposure and Postnatal Autoimmune Disease
Steven D. Holladay
p. 687

The Role of Genetic Factors in Autoimmune Disease: Implications for Environmental Research
Glinda S. Cooper, Frederick W. Miller, and Janardan P. Pandey
p. 693

Neuroendocrine Host Factors and Inflammatory Disease Susceptibility
Sophie Ligier and Esther M. Sternberg
p. 701

Systemic Diseases

Are There Environmental Forms of Systemic Autoimmune Diseases?
Evelyn V. Hess
p. 709

New Zealand Mixed Mice: A Genetic Systemic Lupus Erythematosus Model for Assessing Environmental Effects
Ulrich H. Rudofsky and David A. Lawrence
p. 713

Immunopathogenesis of Environmentally Induced Lupus in Mice
Victoria M. Shaheen, Minoru Satoh, Hanno B. Richards, Hideo Yoshida, Melody Shaw, J. Charles Jennette, and Westley H. Reeves
p. 723

Lupus-Prone Mice as Models to Study Xenobiotic-Induced Acceleration of Systemic Autoimmunity
K. Michael Pollard, Deborah L. Pearson, Per Hultman, Bernhard Hildebrandt, and Dwight H. Kono
p. 729

Environmentally Induced Autoimmune Diseases: Potential Mechanisms
Tharaknath Rao and Bruce Richardson
p. 737

Epidemiologic Studies of Environmental Agents and Systemic Autoimmune Diseases
Maureen D. Mayes
p. 743

Organ-Specific Diseases

Linking Iodine with Autoimmune Thyroiditis
Noel R. Rose, Linda Rasooly, Ali M. Saboori, and C. Lynne Burek
p. 749

Metals and Kidney Autoimmunity
Pierluigi E. Bigazzi
p. 753

Neuroimmunotoxicology: Humoral Assessment of Neurotoxicity and Autoimmune Mechanisms
Hassan A.N. El-Fawal, Stacey J. Waterman, Anthony De Feo, and Magdy Y. Shamy
p. 767

The Role of Environmental Factors in Insulin-Dependent Diabetes Mellitus: An Unresolved Issue
Meredith R. Kraine and Roland M. Tisch
p. 777

Specific Exposures and Mechanisms

The Role of the Immune System in Hexachlorobenzene-Induced Toxicity
Carola C.P.P.C. Michielsen, Henk van Loveren, and Joseph G. Vos
p. 783

Occupational Exposure to Crystalline Silica and Autoimmune Disease
Christine G. Parks, Karsten Conrad, and Glinda S. Cooper
p. 793

Initiation of Autoimmunity by a Reactive Metabolite of a Lupus-Inducing Drug in the Thymus
Robert L. Rubin and Anke Kretz-Rommel
p. 803

Cytokine Regulation of a Rodent Model of Mercuric Chloride-Induced Autoimmunity
Lee M. Bagenstose, Padmini Salgame, and Marc Monestier
p. 807

Workshop Summary and Research Agenda

Linking Environmental Agents and Autoimmune Disease: An Agenda for Future Research
MaryJane K. Selgrade, Glinda S. Cooper, Dori R. Germolec, and Jerrold J. Heindel
p. 811

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