| Liver Angiosarcoma and Hemangiopericytoma after Occupational Exposure to Vinyl Chloride Monomer Izet Hozo,1 Dinko Miric´,2 Lovre Bojic´,3 Lovel Giunio,2 Ivo Lusic´,4 Viktor Culic´,2 and Miroslav Simunic´1 1Department of Gastroenterology and Hepatology, Division of Endoscopic and Ultrasound Investigation; 2Department of Cardiology; 3Department of Ophtalmology; and 4Department of Neurology, Clinical Hospital Split, Split, Croatia Abstract
Various malignant tumors of the liver, especially liver angiosarcoma, have been described after occupational exposure to vinyl chloride monomer. We present the case records and pathologic findings of two plastic industry workers who had been exposed to high concentrations of vinyl chloride. These workers developed hepatic neoplasms, angiosarcoma, or hemangiopericytoma. We discuss the histogenesis of these tumors ; the common vascular origin and the mutual transformation of these two tumors suggest that the hemangiopericytoma may also have developed during occupational exposure to high concentrations of vinyl chloride monomer. Key words: hemangiopericytoma, liver angiosarcoma, vinyl chloride. Environ Health Perspect 108:793-795 (2000) . [Online 13 July 2000] http://ehpnet1.niehs.nih.gov/docs/2000/108p793-795hozo/ abstract.html Address correspondence to I. Hozo, Department of Gastroenterology and Hepatology, Clinical Hospital Split, Pujanke 57/VI, 21 000 Split, Croatia. Telephone/fax: 385 21 376 304. E-mail: Izet.Hozo@st.tel.hr Received 12 October 1999 ; accepted 20 April 2000.
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