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Research Article
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| Disposition of Orally Administered 2,2-Bis(4-hydroxyphenyl)propane (Bisphenol A) in Pregnant Rats and the Placental Transfer to Fetuses Osamu Takahashi and Shinshi Oishi Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Tokyo, Japan Abstract
We studied the disposition of bisphenol A (BPA) in pregnant female F344/DuCrj(Fischer) rats and its placental transfer to fetuses after a single oral administration of 1 g/kg BPA dissolved in propylene glycol. BPA in maternal blood, liver, and kidney reached maximal concentrations (14.7, 171, and 36µg/g) 20 min after the administration and gradually decreased. The levels were 2-5% of the maximum 6 hr after the administration. The maximal concentration of BPA in fetuses (9 µg/g) was also attained 20 min after the administration. BPA levels then gradually reduced in a similar manner to maternal blood. These results suggest that the absorption and distribution of BPA in maternal organs and fetuses are extremely rapid and that the placenta does not act as a barrier to BPA. Key words: bisphenol A, fetus, placenta, placental transfer. Environ Health Perspect 108:931-935 (2000) . [Online 12 September 2000] http://ehpnet1.niehs.nih.gov/docs/2000/108p931-935takahashi/ abstract.html Address correspondence to O. Takahashi, Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 24-1, Hyakunincho 3-chome, Shinjuku-ku, Tokyo 169-0073, Japan. Telephone: 81-3-3363-3231 ext. 5602. Fax: 81-3-3368-4060. E-mail: osamu@tokyo-eiken.go.jp This study was presented at the 26th annual meeting of the Japanese Society of Toxicology held 21-23 July 1999 in Sapporo, Japan. Received 29 February 2000 ; accepted 24 May 2000.
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