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| Biologically Based Dose-Response Model for Liver Tumors Induced by Trichloroethylene Chao W. Chen National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC USA Abstract
The existing extensive laboratory data on trichloroethylene (TCE) and its two metabolites, dichloroacetic (DCA) and trichloroacetic (TCA) , are used to explore the relationship among these three compounds. Under the hypothesis that these compounds induce liver tumors in mice through promotion of preexisting initiated cells, it is demonstrated that DCA alone could be responsible for all the response of carcinomas in liver of B6CF1 mice. The focus of this paper is on how a plausible biological assumption could impact on low-dose risk estimates, rather than on the risk estimate per se. The findings suggest that low-dose risk estimates to humans would be overestimated unless the different background rates between mice and humans are properly accounted for. Key words: DCA, dose-response model, liver tumor, TCA, TCE. -- Environ Health Perspect 108(suppl 2) :335-342 (2000) . http://ehpnet1.niehs.nih.gov/docs/2000/suppl-2/335-342chen/abstract.html
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