| Critical Periods of Vulnerability for the Developing Nervous System: Evidence from Humans and Animal Models Deborah Rice1 and Stan Barone Jr.2 1National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, D.C., USA; 2Cellular and Molecular Toxicology Branch, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA Abstract
Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes (i.e., proliferation, migration, differentiation, synaptogenesis, myelination, and apoptosis) . Evidence from numerous sources demonstrates that neural development extends from the embryonic period through adolescence. In general, the sequence of events is comparable among species, although the time scales are considerably different. Developmental exposure of animals or humans to numerous agents (e.g., X-ray irradiation, methylazoxymethanol, ethanol, lead, methyl mercury, or chlorpyrifos) demonstrates that interference with one or more of these developmental processes can lead to developmental neurotoxicity. Different behavioral domains (e.g., sensory, motor, and various cognitive functions) are subserved by different brain areas. Although there are important differences between the rodent and human brain, analogous structures can be identified. Moreover, the ontogeny of specific behaviors can be used to draw inferences regarding the maturation of specific brain structures or neural circuits in rodents and primates, including humans. Furthermore, various clinical disorders in humans (e.g., schizophrenia, dyslexia, epilepsy, and autism) may also be the result of interference with normal ontogeny of developmental processes in the nervous system. Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function. This concern is compounded by the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans. Key words: abnormal neurological development, apoptosis, behavioral testing methodology, delayed neurotoxicity, differentiation, migration, myelination, neurobiological substrates of function, neuronal plasticity, neurotrophic factor, primate, rodent. -- Environ Health Perspect 108(suppl 3) :511-533 (2000) . http://ehpnet1.niehs.nih.gov/docs/2000/suppl-3/511-533rice/abstract.html
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