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| Application of Genomics to Toxicology Research Russell S. Thomas,1,2 David R. Rank,2 Sharron
G. Penn,2 Gina M. Zastrow,1 Kevin R. Hayes,1
Tianhua Hu,2 Kalyan Pande,1 Mark Lewis,2
Stevan B. Jovanovich,2 and Christopher A. Bradfield1 1McArdle Laboratory for Cancer Research, University of
Wisconsin Medical School, Madison, Wisconsin, USA; 2Amersham
Biosciences, Sunnyvale, California, USA
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Abstract
Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology: toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility. Key words: gene expression, genomics, microarrays, polymorphisms, SNP, species extrapolation, susceptibility, toxicogenomics, toxicology. Environ Health Perspect 110(suppl 6) :919-923 (2002) . http://ehpnet1.niehs.nih.gov/docs/2002/suppl-6/919-923thomas/abstract.html
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