| Use of QSARs in International Decision-Making Frameworks to Predict Health Effects of Chemical Substances Mark T.D. Cronin,1 Joanna S. Jaworska,2 John D. Walker,3 Michael H.I. Comber,4 Christopher D. Watts,5 and Andrew P. Worth6 1School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, England; 2Procter & Gamble, Eurocor, Strombeek-Bever, Belgium; 3TSCA Interagency Testing Committee, U.S. Environmental Protection Agency, Washington, DC 20460, USA; 4Product Stewardship & Regulatory Affairs, ExxonMobil Biomedical Sciences Inc., Machelen, Belgium; 5WRc-NSF, National Centre for Environmental Toxicology, Marlow, Bucks, England; 6European Chemicals Bureau, Institute for Health & Consumer Protection, Joint Research Centre, European Commission, Ispra, Italy
Abstract
This article is a review of the use of quantitative (and qualitative) structure-activity relationships (QSARs and SARs) by regulatory agencies and authorities to predict acute toxicity, mutagenicity, carcinogenicity, and other health effects. A number of SAR and QSAR applications, by regulatory agencies and authorities, are reviewed. These include the use of simple QSAR analyses, as well as the use of multivariate QSARs, and a number of different expert system approaches. Key words: chemical substances, human health effects, prediction, QSAR, regulatory agencies, toxicity. Environ Health Perspect 111:1391-1401 (2003) . doi:10.1289/ehp.5760 available via http://dx.doi.org/ [Online 6 February 2002]
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