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Mini-Monograph
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| Protein Digestibility and Relevance to Allergenicity Gary Bannon,1 Tong-Jen Fu,2 Ian Kimber,3
and Dennis M. Hinton4 1Product Safety Center, Monsanto, St. Louis, Missouri, USA;
2National Center for Food Safety and Technology, U.S. Food
and Drug Administration, Summit-Argo, Illinois, USA; 3Syngenta
Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire,
United Kingdom; 4Center for Food Safety and Applied Nutrition,
U.S. Food and Drug Administration, Laurel, Maryland, USA
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| Abstract
In January 2001 a Joint Food and Agriculture Organization of the United Nations/World Health Organization Expert Consultation Committee on Allergenicity of Foods Derived from Biotechnology published a report outlining in detail an approach for assessing the allergenic potential of novel proteins. One component of this decision tree is a determination of whether the protein of interest is resistant to proteolytic digestion. Although these in vitro methodologies have been useful, the correlation between resistance to proteolysis and allergenic activity is not absolute. Two views and highlights of supporting research regarding the relationship of resistance to digestion and allergenicity are presented in this article. Key words: allergenicity, protein stability, protein structure, proteolytic digestion, safety assessment, sequence homology, simulated gastric fluid. Environ Health Perspect 111:1122-1124 (2003) . doi:10.1289/ehp.5812 available via http://dx.doi.org/ [Online 19 December 2002]
This article is part of the mini-monograph "Assessment of the Allergenic Potential of Genetically Modified Foods." Address correspondence to D.M. Hinton, U.S. FDA, 8301 Muirkirk Rd., Laurel, MD 20878-2476 USA. Telephone: (301) 827-8274. Fax: (301) 594-0517. E-mail: dmhinton@cfsan.fda.gov The authors declare they have no conflict of interest. Received 31 May 2002 ; accepted 19 December 2002.
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