| Assessment of Protein Allergenicity on the Basis of Immune Reactivity: Animal Models Ian Kimber,1 Rebecca J. Dearman,1 Andre H.
Penninks,2 Leon M.J. Knippels,2 Robert B. Buchanan,3
Bruce Hammerberg,4 Hilary A. Jackson,5 and Ricki
M. Helm6 1Syngenta Central Toxicology Laboratory, Alderley Park,
Macclesfield, Cheshire, United Kingdom; 2Experimental Immunology,
Department of Target Organ Toxicology, TNO Nutrition and Food Research,
Zeist, The Netherlands; 3Department of Plant and Microbial
Biology, University of California Berkeley, Berkeley, California, USA;
4Department of Microbiology, Pathology and Parasitology and
5Department of Clinical Sciences, College of Veterinary Medicine,
North Carolina State University, Raleigh, North Carolina, USA; 6Department
of Pediatrics, Arkansas Childrens Hospital Research Institute, University
of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
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| Abstract
Because of the public concern surrounding the issue of the safety of genetically modified organisms, it is critical to have appropriate methodologies to aid investigators in identifying potential hazards associated with consumption of foods produced with these materials. A recent panel of experts convened by the Food and Agriculture Organization and World Health Organization suggested there is scientific evidence that using data from animal studies will contribute important information regarding the allergenicity of foods derived from biotechnology. This view has given further impetus to the development of suitable animal models for allergenicity assessment. This article is a review of what has been achieved and what still has to be accomplished regarding several different animal models. Progress made in the design and evaluation of models in the rat, the mouse, the dog and in swine is reviewed and discussed. Key words: allergy, dog, hazard identification, IgE, IgG, immunogenicity, mouse, rat, risk assessment, swine. Environ Health Perspect 111:1125-1130 (2003) .
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