| DNA Damage Associated with Ultrastructural Alterations in Rat Myocardium after Loud Noise Exposure Paola Lenzi, Giada Frenzilli, Marco Gesi, Michela Ferrucci, Gloria Lazzeri, Francesco Fornai, and Marco Nigro Dipartimento di Morfologia Umana e Biologia Applicata, University of Pisa, Pisa, Italy Abstract
Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyocytes. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage, accompanied by swelling of mitochondrial membranes, dilution of the matrix, and cristolysis. These alterations were concomitant with increased in situ noradrenaline levels and utilization. Genetic and ultrastructural alterations did not decrease 24 hr after the cessation of the stimulus. An elevated oxyradical generation, possibly related to altered sympathetic innervation, is hypothesized as responsible for the induction and persistence of noise-induced cellular damage. Key words: comet assay, DNA damage, loud noise, mitochondria, myocardium, rat. Environ Health Perspect 111:467-471 (2003) .
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