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Gloria D. Jahnke,¹ Neepa Y. Choksi,² John A. Moore,³ and Michael D. Shelby²

¹Sciences International, Inc., Research Triangle Park, North Carolina, USA; ²National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; ³Sciences International, Inc., Alexandria, Virginia, USA

Abstract
A thyroid toxicant workshop sponsored by the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction convened on 28-29 April 2003 in Alexandria, Virginia. The purpose of this workshop was to examine and discuss chemical-induced thyroid dysfunction in experimental animals and the relevance of reproductive and developmental effects observed for prediction of adverse effects in humans. Presentations highlighted and compared reproductive and developmental effects of thyroid hormones in humans and rodents. Rodent models of thyroid system dysfunction were presented. Animal testing protocols were reviewed, taking into account protocol designs that allow extrapolation to possible human health effects. Potential screening methods to assess toxicant-induced thyroid dysfunction were outlined, and postnatal bioassays of thyroid-related effects were discussed. Key words: chemical screening, chemical testing, developmental, perinatal exposure, reproductive, thyroid gland, thyroid hormones, toxicology. Environ Health Perspect 112:363-368 (2004) . doi:10.1289/ehp.6637 available via http://dx.doi.org/ [Online 12 November 2003]

Address correspondence to G.D. Jahnke, NTP-CERHR, National Institute of Environmental Health Sciences, MD EC-32, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3376. Fax: (919) 316-4511. E-mail: jahnke@niehs.nih.gov

This workshop was sponsored by the National Toxicology Program Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR) , NIEHS, NIH, and DHHS and supported under NTP/NIEHS contract N01-ES-85425. Copies of the background document for this workshop are available from M.D. Shelby, Director, NTP-CERHR, MD EC-32, P.O. Box 12233, Research Triangle Park, NC 27709 USA ; E-mail: shelby@niehs.nih.gov

Conference organizers: M.D. Shelby, J.A. Moore. Workshop Chair: M.D. Shelby. Speakers: G. Brent, P.S. Cooke, D.R. Doerge, J.F. Holson, R. Kavlock, L.D. Lehman-McKeeman, J.A. Moore, S. Refetoff, R. Weiss, R.T. Zoeller.

The authors declare they have no competing financial interests.

Received 6 August 2003 ; accepted 12 November 2003.