| Workgroup Report: National Toxicology Program Workshop on Hormonally Induced Reproductive Tumors—Relevance of Rodent Bioassays Kristina A. Thayer and Paul M. Foster National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Abstract
The National Toxicology Program (NTP) is currently reviewing its research portfolio as part of its efforts to implement the NTP Roadmap to achieve the NTP Vision for the 21st century. This review includes a recent workshop, "Hormonally Induced Reproductive Tumors—Relevance of Rodent Bioassays," held 22–24 May 2006, that was organized to determine the adequacy and relevance to human disease outcome of rodent models used in the 2-year bioassay for four types of hormonally induced reproductive tumors (ovary, mammary gland, prostate, and testis) . In brief, none of the workshop's breakout groups felt the currently used models are sufficient. For some types of tumors such as prostate, no adequate animal models exist, and for others such as ovary, the predominant tumors in humans are of different cellular origins than those induced by chemicals in rodents. This inadequacy of current models also applies to the testis, although our more complete understanding of the responses of Leydig cells to hormonal changes in rats may prove predictive for effects in humans other than cancer. All breakout groups recommended that the NTP consider modifying its testing protocols (i.e., age at exposure, additional end points, etc.) and/or using alternative models (i.e., genetically engineered models, in vitro systems, etc.) to improve sensitivity. In this article we briefly review the workshop's outcome and outline some next steps forward in pursuing the workshop's recommendations. Breakout group reports and additional information on the workshop, including participants, presentations, public comments and background materials, are posted on the NTP website. Key words: animal models, breast, endocrine, hormone, mammary gland, National Toxicology Program, ovary, prostate, reproductive tumors, species differences, testis. Environ Health Perspect 115:1351–1356 (2007) . doi:10.1289/ehp.10135 available via http://dx.doi.org/ [Online 5 July 2007]
Address correspondence to P. Foster, NIEHS, EC-34, PO Box 12233, Research Triangle Park, NC, 27709 USA.Telephone: (919) 541-2513. Fax: (919) 541-4255. E-mail: foster2@niehs.nih.gov The NTP recognizes the contributions of all the workshop participants. This workshop was supported by the Intramural Research Program of the NIEHS, NIH. The authors declare they have no competing financial interests. Received 2 February 2007 ; accepted 5 July 2007.
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