Environmental Health Perspectives Volume 107, Number 8, August 1999
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Application of DNA Arrays to Toxicology
John C. Rockett and David J. Dix
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Abstract
DNA array technology makes it possible to rapidly genotype individuals or quantify the expression of thousands of genes on a single filter or glass slide, and holds enormous potential in toxicologic applications. This potential led to a U.S. Environmental Protection Agency-sponsored workshop titled "Application of Microarrays to Toxicology" on 7-8 January 1999 in Research Triangle Park, North Carolina. In addition to providing state-of-the-art information on the application of DNA or gene microarrays, the workshop catalyzed the formation of several collaborations, committees, and user's groups throughout the Research Triangle Park area and beyond. Potential application of microarrays to toxicologic research and risk assessment include genome-wide expression analyses to identify gene-expression networks and toxicant-specific signatures that can be used to define mode of action, for exposure assessment, and for environmental monitoring. Arrays may also prove useful for monitoring genetic variability and its relationship to toxicant susceptibility in human populations. Key words: DNA arrays, gene arrays, microarrays, toxicology. Environ Health Perspect 107:681-685 (1999). [Online 6 July 1999]
http://ehpnet1.niehs.nih.gov/docs/1999/107p681-685rockett/abstract.html
Address correspondence to J. Rockett, Reproductive Toxicology Division (MD-72), National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC 27711 USA. Telephone: (919) 541-2678. Fax: (919) 541-4017. E-mail: rockett.john@epa.gov
The authors thank R. Kavlock for envisioning the application of array technology to toxicology at the U.S. Environmental Protection Agency. We also thank T. Wall and B. Deitz for administrative assistance.
This document has been reviewed in accordance with EPA policy and approved for publication. Mention of companies, trade names, or products does not signify endorsement of such by the EPA.
Received 23 March 1999; accepted 22 April 1999.
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Last Updated: July 6, 1999